Role of mitochondrial dysfunction in cardiac glycoside toxicity
نویسندگان
چکیده
منابع مشابه
An unusual case of cardiac glycoside toxicity.
a Cardiovascular Disease Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, United States b Pulmonary Disease and Critical Care Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, United States c Internal Medicine Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, United ...
متن کاملthe role of oxidative stress in metals toxicity; mitochondrial dysfunction as a key player
metals can cause oxidative stress by increasing the formation of reactive oxygen species (ros), which make antioxidants incapable of defiance against growing amounts of free radicals. metal toxicity is related to their oxidative state and reactivity with other compounds. however, several reports about metals have been published in the recent years. mitochondria, as a site of cellular oxygen con...
متن کاملCardiac Dysfunction in Mitochondrial Disease
(mtDNA) disease and the frequency of cardiac involvement, at least 1 in 10–15,000 of the general population will be affected.4 In 1991, the first mtDNA point mutation in the MT-TL1 gene associated with an MCM was described.5 Since then, several mutations, mostly in mitochondrial tRNA genes, have been associated with different MCM phenotypes. At the end of the 20th century, mutations in several ...
متن کاملINOTROPY AND TOXICITY OF A POLAR CARDIAC GLYCOSIDE/Mudge
17. Ito CS, Scher AM: Reflexes from the aortic baroreceptor fibers in the cervical vagus of the cat and dog. Circ Res 34: 51-60, 1974 18. Thoren PN, Mancia G, Shepherd JT: Vasomotor inhibition in rabbits by vagal nonmedullated fibers from cardiopulmonary area. Am J Physiol 229: 1410-1413, 1975 19. Paintal AS: Vagal sensory receptors and their reflex effects. Physiol Rev 53: 159-227, 1973 20. Ob...
متن کاملMitochondrial DNA, mitochondrial dysfunction, and cardiac manifestations.
Mitochondria, are the powerhouses of cells, have their own DNA (mtDNA), regulate the transport of metabolites and ions, and impact cell physiology, survival, and death. Mitochondrial dysfunction, including impaired oxidative phosphorylation, preferentially affects heart function due to an imbalance of energy supply and demand. Recently, mitochondrial mutations and associated mitochondrial dysfu...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2010
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2010.06.012